LEVERAGING THE THERAPEUTIC POTENTIAL OF B- AND T-CELLS
The UCLA Crompton Lab engages in laboratory and clinical investigations to elucidate mechanisms of immunological memory with the aim of developing novel immunotherapies for cancer patients. In particular, we study:
- the induction and composition of intra-tumoral tertiary lymphoid structures, with a current focus on the role of B cells in antigen presentation and generation of a neoantigen specific humoral response.
- the ontogeny of activated CD8 T cells with the aim of elucidating key epigenetic, signal transduction, and metabolic features critical for the development of long-lived memory T cells; previously finding that inhibition of the serine/threonine kinase Akt results in the formation of long-lived T cells with potent anti-tumor activity.